Arsenal defender Mikael Silvestre is a major doubt to play at Old Trafford, according to manager Arsene Wenger.
"I believe the only serious new problem we have is Silvestre, he has a back spasm and is 50-50 for Old Trafford."
Striker Robin van Persie will miss the first leg of the Champions League semi-final against Manchester United because of a groin injury.
Manchester United will again be without defender Gary Neville (foot injury) but have no other fresh injuries.
United may also be boosted by the return of defender Wes Brown, who has only made two substitute appearances since October due to a foot injury.
And Ryan Giggs will be hoping to make his 800th first-team appearance for United after being rested for Saturday's 5-2 victory against Tottenham.
Left back Gael Clichy will not recover in time from his back injury for Wednesday's match though.
"He could be back for the second Manchester United game. He has a scan on Monday. We'll go from there. He has a chance to be back in full training next week," Gunners boss Arsene Wenger told www.arsenal.com.
Better news for the Gunners is that Johan Djourou is fit again following a knee injury which kept him out of the 3-0 quarter-final second leg victory over Villarreal.
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