Manchester United's Ryan Giggs is set to make his 800th for the club against Arsenal in the Champions League semi-final first leg at Old Trafford.
Giggs, recently voted PFA Player of the Year, was rested for the 5-2 Premier League victory against Tottenham Hotspur on Saturday, and could be restored to the starting line-up to face the Gunners.
Should the 35-year-old play then he will captain the side due to the continued absence of club captain Gary Neville, who remains sidelined with a foot injury.
John O'Shea will fill Neville's role at right-back, although fellow defender Wes Brown may return to the squad from injury.
Arsenal will be depleted both in attack and defence for the trip north. Russian forward Andrei Arshavin is cup-tied while Robin van Persie remains out with a groin strain.
However, striker Emmanuel Adebayor and midfielder Abou Diaby should both be available after the pair came off the bench in the 2-0 home win over Middlesbrough at the weekend, with Adebayor likely to play as a lone front man supported by Cesc Fabregas.
At the back William Gallas and Gael Clichy are joined by Mikael Silvestre on the sidelines after the former United defender injured his back against Boro.
That means Johan Djourou will partner Kolo Toure in the heart of the defence, while Bacary Sagna could be return at right-back after being replaced by Emmanuel Eboue at the weekend.
Mexican striker Carlos Vela makes the trip after being told not to attend training on Tuesday over fears about the swine flu outbreak.
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